Sodium valproate and routine liver function tests.

Sodium valproate and routine liver function tests.

Acute liver impairment after sodium valproate overdose.

Liver impairment is a recognised adverse effect of long-term sodium valproate treatment, but there are few reports concerning its occurrence after acute overdose. This report describes a 36-year-old woman who deliberately ingested 32 g of sodium valproate (Epilim). Serum valproate concentration was 4370 μmol/l (630 mg/l) at 4.3 h post-ingestion (therapeutic reference range: 300-600 μmol/l), and...

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Sodium valproate and pregnancy.

Correspondence Sodium valproate and pregnancy Sir, We were presented with a baby born to a mother taking sodium valproate who wished to breast feed. There are no data on breast milk levels of sodium valproate; it is presumed from collateral evidence that some of the drug would pass across from maternal serum into the milk. Studies in animals given modest doses of sodium valproate during pregnan...

Diagnostic value of routine liver tests.

In 131 patients on a medical service and 97 patients on a surgical service, in whom a diagnosis of hepatobiliary disease was verified in the hospital, the diagnostic value of routine liver tests performed soon after admission was evaluated by stepwise discriminant analysis. By measurements of alanine aminotransferase, alkaline phosphatases, gamma globulin, prothrombin time, bilirubin, and album...